Mechanical evaluation of the resistance and elastance of post-burn scars after topical treatment with tretinoin
Clinics
;
66(11): 1949-1954, 2011. ilus
Artigo
em Inglês
| LILACS
| ID: lil-605877
ABSTRACT
OBJECTIVE:
After burn injuries, scarred skin lacks elasticity, especially in hypertrophic scars. Topical treatment with tretinoin can improve the appearance and quality of the skin (i.e., texture, distensibility, color, and hydration). The objective of this prospective study was to examine the effects of treatment with 0.05 percent tretinoin for one year on the biomechanical behavior and histological changes undergone by facial skin with post-burn scarring.Setting:
Tertiary, Institutional.METHOD:
Fifteen female patients who had suffered partial thickness burns with more than two years of evolution were selected. Skin biopsies were obtained initially and after one year of treatment. The resistance and elastance of these skin biopsies were measured using a mechanical oscillation analysis system. The density of collagen fibers, elastic fibers, and versican were determined using immunohistochemical analysis.RESULTS:
Tretinoin treatment significantly lowered skin resistance and elastance, which is a result that indicates higher distensibility of the skin. However, tretinoin treatment did not significantly affect the density of collagen fibers, elastic fibers, or versican.CONCLUSION:
Topical tretinoin treatment alters the mechanical behavior of post-burn scarred skin by improving its distensibility and thus leads to improved quality of life for patients.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Tretinoína
/
Queimaduras
/
Cicatriz Hipertrófica
/
Elasticidade
/
Traumatismos Faciais
/
Ceratolíticos
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
University of São Paulo/BR
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