Markers of insulin resistance and sedentary lifestyle are predictors of preeclampsia in women with adverse obstetric results
Braz. j. med. biol. res
;
44(12): 1285-1290, Dec. 2011. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-606540
ABSTRACT
Some thrombophilias and severe preeclampsia may increase the risk for preterm deliveries and fetal death due to placental insufficiency. Our objective was to evaluate clinical and laboratory data as predictors of preeclampsia in a population of mothers with 3rd trimester fetal losses or preterm deliveries. In a longitudinal retrospective study, 54 consecutive women (age range 16 to 39 years) with normotensive pregnancies were compared to 79 consecutive women with preeclampsia (age range 16 to 43 years). Weight accrual rate (WAR) was arbitrarily defined as weight gain from age 18 years to the beginning of pregnancy divided by elapsed years. Independent predictors of preeclampsia were past history of oligomenorrhea, WAR >0.8 kg/years, pre-pregnancy or 1st trimester triglyceridemia >150 mg/dL, and elevated acanthosis nigricans in the neck. In a multivariate logistic regression model, two or more predictors conferred an odds ratio of 15 (95 percentCI [5.9-37]; P < 0.001) to develop preeclampsia (85 percent specificity, 73 percent sensitivity, c-statistic of 81 ± 4 percent; P < 0.0001). Clinical markers related to insulin resistance and sedentary lifestyles are strong independent predictors of preeclampsia in mothers with 3rd trimester fetal losses or preterm deliveries due to placental insufficiency. Women at risk for preeclampsia in this particular population might benefit from measures focused on overcoming insulin resistance.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pré-Eclâmpsia
/
Resistência à Insulina
/
Comportamento Sedentário
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Recém-Nascido
/
Gravidez
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital Federal dos Servidores do Estado/BR
/
Universidade Gama Filho/BR
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