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Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
Lima, MVA; Nogueira, C; Oliveira, JAA; Muniz Neto, FJ; Franco, M; Tavora, F.
  • Lima, MVA; Instituto do Câncer do Ceara. Hospital do Câncer. Fortaleza.
  • Nogueira, C; Instituto do Câncer do Ceara. Hospital do Câncer. Fortaleza.
  • Oliveira, JAA; Instituto do Câncer do Ceara. Hospital do Câncer. Fortaleza.
  • Muniz Neto, FJ; Instituto do Câncer do Ceara. Hospital do Câncer. Fortaleza.
  • Franco, M; Instituto do Câncer do Ceara. Hospital do Câncer. Fortaleza.
  • Tavora, F; Instituto do Câncer do Ceara. Hospital do Câncer. Fortaleza.
Int. braz. j. urol ; 37(5): 598-604, Sept.-Oct. 2011. ilus, tab
Artigo em Inglês | LILACS | ID: lil-608127
ABSTRACT

PURPOSE:

Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. The objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies. MATERIALS AND

METHODS:

The current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period.

RESULTS:

There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. The number of cores involved in prostates with NEC was greater (65 percent compared to 24 percent of acinar tumors, p < 0.05). The mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy.

CONCLUSIONS:

NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Próstata / Neoplasias da Próstata / Adenocarcinoma / Carcinoma de Células Pequenas / Carcinoma Neuroendócrino / Doenças Raras Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Brasil

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Próstata / Neoplasias da Próstata / Adenocarcinoma / Carcinoma de Células Pequenas / Carcinoma Neuroendócrino / Doenças Raras Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Brasil