Klebsiella ESBL bacteremia-mortality and risk factors
Braz. j. infect. dis
;
15(6): 594-598, Nov.-Dec. 2011. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-610533
ABSTRACT
Background:
Extended spectrum β-lactamase (ESBL)-producing bacteria have become recognized as a problem in South America. The aim of this study was to evaluate risk factors and mortality rate in bacteremia caused by ESBL-producing Klebsiella pneumoniae in a Brazilian hospital.Methods:
A three-year retrospective cohort study with 104 cases of K. pneumoniae bacteremia (61 ESBL and 43 non-ESBL). Several clinical and laboratory variables were evaluated. The outcome of interest was 30-day mortality. The adequate treatment was evaluated according to antibiotic susceptibility.Results:
Multivariable analysis showed that central venous catheter and mechanical ventilation were independent risk factors for ESBL. The duration of hospitalization before the bacteremia was not a risk factor. Mortality was similar in ESBL and non-ESBL and inadequate therapy was not shown to be a risk factor.Conclusion:
ESBL-producing Klebsiella bacteremia can occur early, suggesting that a carbapenem should be included in the initial empirical therapy for bacteremia in patients under mechanical ventilation and/or central venous catheter in our institution.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Beta-Lactamases
/
Infecções por Klebsiella
/
Infecção Hospitalar
/
Bacteriemia
/
Klebsiella pneumoniae
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Aged80
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital Universitário Evangélico de Curitiba/BR
Similares
MEDLINE
...
LILACS
LIS