The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
106(8): 1055-1057, Dec. 2011. ilus, graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-610987
ABSTRACT
In this study we prepared an inclusion complex between an iodide analogue of metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective method of treating Trypanosoma cruzi infections. According to our results, MTZ-I and MTZ-Iβ-CD were 10 times more active than MTZ, demonstrating that the presence of an iodine atom on the side chain increased the trypanocidal activity while maintaining its cytotoxicity. The selective index shows that MTZ-I was 10 times more active against T. cruzi than it was against mammalian cells. The modification of MTZ side chains provides a promising avenue for the development of new drugs.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Tripanossomicidas
/
Trypanosoma cruzi
/
Beta-Ciclodextrinas
/
Metronidazol
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Instituto de Pesquisas René Rachou-Fiocruz/BR
/
Universidade Federal de Minas Gerais/BR
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