Reporte de reacciones adversas a medicamentos con compromiso mucocutáneo en el Hospital Clínico Universidad de Chile durante los años 2004-2010 / Report of adverse reactions to medecines with mucocutáneo commitment in the Hospital Clínico Universidad de Chile during years 2004-2010
Rev. Hosp. Clin. Univ. Chile
;
22(2): 104-112, 2011.
Artigo
em Espanhol
| LILACS
| ID: lil-613258
ABSTRACT
Adverse drug reactions (ADRs) are responsible for up to 10percent of hospital admissions worldwide; within them, that mucocutaneous reactions are the most common represented 30percent of the total. The aim of this study was to analyze 119 reports of ADRs recorded in the Pharmacy Department of University of Chile Clinical Hospital in the period 2004-2010 by gender, age, most frequent clinical presentations, drugs and health personnel linked to the notification. In addition, we tried to quantify the relative importance of mucocutaneous reactions in the total of reported ADRs. ADRs were more common in women (56.3percent). The average age was 52.84 years + / - 7.77, 52.07 + / - 10.6 for women and 53.84 + / - 13.43 for men without significant differences (p = 0.85). According to the clinical presentation, mucocutaneous reactions were the most frequent (31.1percent) followed by hematological (25.2percent). The drugs involved were chemotherapy (68.9percent), antibiotics (5.9percent) and NSAIDs, nonsteroidal anti-inflammatory drugs, (4.2percent). In health personnel linked to the notification, we found the association medical / pharmaceutical chemist was the most frequent (40.3percent), followed by a pharmaceutical chemist (33.6percent). In mucocutaneous ADRs we observed a mean age of 54.65 + / - 9.19 years and female predominance (62.2percent). According to the clinical dermatology, we observed a prevalence of skin rash (35.1percent), mucositis (21.6percent), facial erythema (16.2percent) and pruritus (16.2percent). The drugs involved were chemotherapy (78.4percent), antibiotics (8percent), antiretroviral therapy (5percent) and opioids (5percent). Finally, we found that according to time of onset, delayed reactions were the most frequent (43.2percent).
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Preparações Farmacêuticas
/
Sistemas de Notificação de Reações Adversas a Medicamentos
/
Toxidermias
Tipo de estudo:
Estudos de avaliação
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. Hosp. Clin. Univ. Chile
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Hospital Clínico de la Universidad de Chile/CL
/
Universidad de Chile/CL
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