Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models
Braz. j. med. biol. res
;
45(2): 147-152, Feb. 2012. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-614567
ABSTRACT
Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2 percent lidocaine or tramadol (1.25 and 5 mg) was perineurally injected in two different animal pain models. In the flinching behavior test, the number of flinches was evaluated and in the plantar incision model, mechanical and heat thresholds were measured. Motor effects of lidocaine and tramadol were quantified and a motor block score elaborated. Tramadol, 1.25 mg, completely blocked the first and reduced the second phase of the flinching behavior test. In the plantar incision model, tramadol (1.25 mg) increased both paw withdrawal latency in response to radiant heat (8.3 ± 1.1, 12.7 ± 1.8, 8.4 ± 0.8, and 11.1 ± 3.3 s) and mechanical threshold in response to von Frey filaments (459 ± 82.8, 447.5 ± 91.7, 320.1 ± 120, 126.43 ± 92.8 mN) at 5, 15, 30, and 60 min, respectively. Sham block or contralateral sciatic nerve block did not differ from perineural saline injection throughout the study in either model. The effect of tramadol was not antagonized by intraperitoneal naloxone. High dose tramadol (5 mg) blocked motor function as well as 2 percent lidocaine. In conclusion, tramadol blocks nociception and motor function in vivo similar to local anesthetics.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Nervo Isquiático
/
Tramadol
/
Medição da Dor
/
Analgésicos Opioides
/
Bloqueio Nervoso
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital Santa Paula/BR
/
Universidade de São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS