Efecto de las hormonas tímicas sobre la síntesis de IL-4 / Effect of thymic hormones over the synthesis of IL-4
Prensa méd. argent
;
98(3): 133-139, 2011. tab
Artigo
em Espanhol
| LILACS
| ID: lil-616804
ABSTRACT
A thymic hormone baptized as thymostimulin coming from children aged between 5-10 years who died after car accidents was obtained by Sephadex G-50 column fractionation. This polypeptide was incubated with atopic and non-atopic human lymphocytes. The level of IL-4 in the supernatant was measured by ELISA. The atopic lymphocytes stimulated by the thymostimulin produced a great quantity of IL-4 (p>0.000001) in comparison with those coming from non-atopic patients. Thus, we postulate that thymic hormones should not be used in the treatment of allergic conditions with high levels of IL-4. The function of this polypeptide was compared with that of bovine timomodulin, which showed lower level of IL-4 (p>_ 0.001).
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Índice:
LILACS (Américas)
Assunto principal:
Timo
/
Hormônios do Timo
/
Ensaio de Imunoadsorção Enzimática
/
Interpretação Estatística de Dados
Limite:
Criança
/
Criança, pré-escolar
/
Humanos
Idioma:
Espanhol
Revista:
Prensa méd. argent
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad de Buenos Aires/AR
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