T-Cell Lymphomas in South America and Europe
Rev. bras. hematol. hemoter
;
34(1): 42-47, 2012. tab
Artigo
em Inglês
| LILACS
| ID: lil-618302
ABSTRACT
Peripheral T-cell lymphomas are a group of rare neoplasms originating from clonal proliferation of mature post-thymic lymphocytes with different entities having specific biological characteristics and clinical features. As natural killer cells are closely related to T-cells, natural killer-cell lymphomas are also part of the group. The current World Health Organization classification recognizes four categories of T/natural killer-cell lymphomas with respect to their presentation: disseminated (leukemic), nodal, extranodal and cutaneous. Geographic variations in the distribution of these diseases are well documented: nodal subtypes are more frequent in Europe and North America, while extranodal forms, including natural killer-cell lymphomas, occur almost exclusively in Asia and South America. On the whole, T-cell lymphomas are more common in Asia than in western countries, usually affect adults, with a higher tendency in men, and, excluding a few subtypes, usually have an aggressive course and poor prognosis. Apart from anaplastic lymphoma kinase-positive anaplastic large cell lymphoma, that have a good outcome, other nodal and extranodal forms have a 5-year overall survival of about 30 percent. According to the principal prognostic indexes, the majority of patients are allocated to the unfavorable subset. In the past, the rarity of these diseases prevented progress in the understanding of their biology and improvements in the efficaciousness of therapy. Recently, international projects devoted to these diseases created networks promoting investigations on T-cell lymphomas. These projects are the basis of forthcoming cooperative, large scale trials to detail biologic characteristics of each sub-entity and to possibly individuate targets for new therapies.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Prognóstico
/
Células Matadoras Naturais
/
Linfoma de Células T
/
Neoplasias Hematológicas
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Argentina
/
Brasil
/
Canadá
/
Chile
/
China
/
Israel
/
Itália
/
Suíça
/
Estados Unidos
/
Reino Unido
Instituição/País de afiliação:
British Columbia Cancer Agency/CA
/
Faculdade de Ciências Médicas da Santa Casa de São Paulo/BR
/
Fundaleu/AR
/
Hadassah MedicalCenter/IL
/
Hospital Del Salvador/CL
/
Hospital Italiano de La Plata/AR
/
Hospital Maciel/UY
/
Hospital San Martín de La Plata/AR
/
Istituto Oncologico della Svizzera Italiana/CH
/
L'Università di Bologna/IT
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