Antitumor properties of ganoderma lucidum polysaccharidesand terpenoids: [review]

ABSTRACT

Ganoderma lucidum is an edible medicinal mushroom withimmunomodulatory and antitumor properties, which are mainly attributed to polysaccharides and triterpenesthat can be isolated from mycelia, fruiting bodies and spores. G. lucidum has been used in a powdered form, asa medicinal beverage and a nutraceutical food (usually dried). In the present review we report some historicalfacts and the experimental evidence that polysaccharides and triterpenes obtained from this mushroom presentpotential antitumor activity. Direct effects on tumor cells include induction of apoptosis and interference in thecell cycle, whereas indirect effects are based on the modulation of immune response, usually impaired bycancer cells. Data indicate that G. lucidum can be used as a complementary tool for treatment of cancerpatients.