The use of interferons in the treatment of pre-invasive cervical neoplasias
ARBS annu. rev. biomed. sci
;
13(n.esp): 17-22, 2011. ilus
Artigo
em Inglês
| LILACS
| ID: lil-619904
ABSTRACT
The evolution of cervical intraepithelial neoplasias(CINs) can lead to the development of cervical carcinomas and is closely tied to infection with human papillomavirus (HPV). Interferon (IFN)s antitumor effects have a direct bearing on the proliferation or antigen composition of tumor cells, and act on specific tumor cells through immunomodulation. Moreover, some studies have indicated that type 1 IFN can have an antitumor effect by increasing levels of cytotoxic T cells,natural killer (NK) cells and dendritic cells (DCs). Immunotherapy with IFN has recently been used on cervical intraepithelial lesions and invasive cervical cancer with promising results. The objective of this mini-review isto discuss IFNs function, importance, and mechanism of action in the treatment of pre-malignant cervicalneoplasias.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Displasia do Colo do Útero
/
Interferons
Limite:
Humanos
Idioma:
Inglês
Revista:
ARBS annu. rev. biomed. sci
Assunto da revista:
Biologia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of the Triângulo Mineiro/BR
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