Variabilidad genética del virus hepatitis B y su significado clínico / Genetic variability hepatitis b virus, the clinical meaning
Rev. Hosp. Clin. Univ. Chile
;
21(2): 154-161, 2010. ilus
Artigo
em Espanhol
| LILACS
| ID: lil-620979
ABSTRACT
The Hepatitis B virus (HBV) is the prototype member of the Hepadnaviridae family, which can cause acute or chronic hepatic illness. The virus has a partially double-stranded DNA genome of3.2 kb. Molecular variations and change in the genome over time have resulted in the emergence of at least eight genotypes and multiple subgenotypes. The distribution of HBV genotypes varies widely across geographic regions, been the genotype F the most prevalent in Chile. In recent years, substantial progress has been made toward understanding the epidemiology and virologic significance of HBV variants. Actually, accumulating evidence suggests that hepatitis B genotypes and subgenotypes can influence the severity, course and likelihood of complications, and response to treatment of HBV infection and possibly vaccination against the virus.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vírus da Hepatite B
/
Genoma
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. Hosp. Clin. Univ. Chile
Assunto da revista:
Medicina
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Facultad de Medicina Universidad de Chile/CL
/
Hospital Clínico Universidad de Chile/CL
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