Metabolic syndrome in patients with chronic hepatitis C virus genotype 1 infection who do not have obesity or type 2 diabetes
Clinics
;
67(3): 219-223, 2012. tab
Artigo
em Inglês
| LILACS
| ID: lil-623094
ABSTRACT
OBJECTIVE:
The individual components of metabolic syndrome may be independent predictors of mortality in patients with liver disease. We aimed to evaluate the prevalence of metabolic syndrome and its related components in hepatitis C virus-infected patients who are not obese and do not have type 2 diabetes.METHODS:
This cross-sectional study included 125 patients infected with hepatitis C virus genotype 1. Metabolic syndrome was defined according to the International Diabetes Federation. Anthropometric data were measured according to standardized procedures. Bioimpedance analysis was performed on all patients.RESULTS:
Metabolic syndrome was diagnosed in 21.6% of patients. Of the subjects with metabolic syndrome, 59.3% had hypertension, 77.8% had insulin resistance, 85.2% were overweight, 48.1% had a high waist circumference, 85.2% had an increased body fat percentage, and 92.3% had an elevated waisthip ratio. In the bivariate analysis, female sex (OR 2.58; 95% CI 1.09-6.25), elevated gamma-glutamyl transferase (γGT) (OR 2.63; 95% CI 1.04-7.29), elevated fasting glucose (OR 8.05; 95% CI 3.17-21.32), low HDL cholesterol (OR 2.80; 95% CI 1.07-7.16), hypertriglyceridemia (OR 7.91; 95% CI 2.88-22.71), elevated waist circumference (OR 10.33; 95% CI 3.72-30.67), overweight (OR 11.33; 95% CI 3.97-41.07), and increased body fat percentage (OR 8.34; 95% CI 2.94-30.08) were independent determinants of metabolic syndrome. Using the final multivariate regression model, similar results were observed for abdominal fat (OR 9.98; 95% CI 2.63-44.41) and total body fat percentage (OR 8.73; 95% CI 2.33-42.34). However, metabolic syndrome risk was also high for those with blood glucose >5.55 mmol/L or HDL cholesterol <0.9 mmol/L (OR 16.69; 95% CI 4.64-76.35; OR 7.23; 95% CI 1.86-32.63, respectively).CONCLUSION:
Metabolic syndrome is highly prevalent among hepatitis C virus-infected patients without type 2 diabetes or obesity. Metabolic syndrome was significantly associated with hypertension, insulin resistance, increased abdominal fat, and overweight.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hepatite C Crônica
/
Síndrome Metabólica
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of Bahia/BR
/
Federal University of Bahia, Medicine and Health/BR
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