Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients
Clinics
;
67(4): 313-318, 2012. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-623109
ABSTRACT
OBJECTIVE:
To describe the chest computed tomography findings for severe influenza H1N1 infection in a series of hospitalized neutropenic cancer patients.METHODS:
We performed a retrospective systematic analysis of chest computed tomography scans for eight hospitalized patients with fever, neutropenia, and confirmed diagnoses of influenza H1N1. The clinical data had been prospectively collected.RESULTS:
Six of eight patients (75%) developed respiratory failure and required intensive care. Prolonged H1N1 shedding was observed in the three mechanically ventilated patients, and overall hospital mortality in our series was 25%. The most frequent computed tomography findings were ground-glass opacity (all patients), consolidation (7/8 cases), and airspace nodules (6/8 cases) that were frequently moderate or severe. Other parenchymal findings were not common. Five patients had features of pneumonia, two had computed tomography findings compatible with bronchitis and/or bronchiolitis, and one had tomographic signs of chronicity.CONCLUSION:
In this series of neutropenic patients with severe influenza H1N1 infection, chest computed tomography demonstrated mainly moderate or severe parenchymatous disease, but bronchiolitis was not a common feature. These findings associated with febrile neutropenia should elicit a diagnosis of severe viral infection.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pneumonia Viral
/
Tomografia Computadorizada por Raios X
/
Influenza Humana
/
Vírus da Influenza A Subtipo H1N1
/
Neoplasias
/
Neutropenia
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Criança, pré-escolar
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
D'Or Institute for Research and Education/BR
/
Federal University of Rio de Janeiro/BR
/
Instituto Nacional de Câncer/BR
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