Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients
Clinics
; 67(4): 313-318, 2012. ilus, tab
Article
em En
| LILACS
| ID: lil-623109
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
To describe the chest computed tomography findings for severe influenza H1N1 infection in a series of hospitalized neutropenic cancer patients.METHODS:
We performed a retrospective systematic analysis of chest computed tomography scans for eight hospitalized patients with fever, neutropenia, and confirmed diagnoses of influenza H1N1. The clinical data had been prospectively collected.RESULTS:
Six of eight patients (75%) developed respiratory failure and required intensive care. Prolonged H1N1 shedding was observed in the three mechanically ventilated patients, and overall hospital mortality in our series was 25%. The most frequent computed tomography findings were ground-glass opacity (all patients), consolidation (7/8 cases), and airspace nodules (6/8 cases) that were frequently moderate or severe. Other parenchymal findings were not common. Five patients had features of pneumonia, two had computed tomography findings compatible with bronchitis and/or bronchiolitis, and one had tomographic signs of chronicity.CONCLUSION:
In this series of neutropenic patients with severe influenza H1N1 infection, chest computed tomography demonstrated mainly moderate or severe parenchymatous disease, but bronchiolitis was not a common feature. These findings associated with febrile neutropenia should elicit a diagnosis of severe viral infection.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Pneumonia Viral
/
Tomografia Computadorizada por Raios X
/
Influenza Humana
/
Vírus da Influenza A Subtipo H1N1
/
Neoplasias
/
Neutropenia
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Child, preschool
/
Female
/
Humans
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article