A new scenario of bioprospecting of Hymenoptera venoms through proteomic approach
J. venom. anim. toxins incl. trop. dis
;
17(4): 364-377, 2011. ilus
Artigo
em Inglês
| LILACS
| ID: lil-623499
ABSTRACT
Venoms represent a huge and essentially unexplored reservoir of bioactive components that may cure diseases that do not respond to currently available therapies. This review select advances reported in the literature from 2000 to the present about the new scenario of Hymenoptera venom composition. On account of new technologies in the proteomic approach, which presents high resolution and sensitivity, the combination of developments in new instruments, fragmentation methods, strategic analysis, and mass spectrometry have become indispensable tools for interrogation of protein expression, molecule interaction, and post- translational modifications. Thus, the biochemical characterization of Hymenoptera venom has become a major subject of research in the area of allergy and immunology, in which proteomics has been an excellent alternative to assist the development of more specific extracts for diagnosis and treatment of hypersensitive patients to Hymenoptera venoms.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Espectrometria de Massas
/
Venenos de Vespas
/
Venenos de Abelha
/
Proteômica
/
Himenópteros
/
Hipersensibilidade
Limite:
Animais
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Institute of Biosciences/BR
/
São Paulo State University/BR
/
University of Sorocaba/BR
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