The immune-dependence of chemotherapy in experimental schistosomiasis
Mem. Inst. Oswaldo Cruz
; 84(supl.1): 31-37, 1989.
Article
em En
| LILACS
| ID: lil-623563
Biblioteca responsável:
BR1.1
ABSTRACT
Experimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by T cell-deprivation, than against comparable infection in normal mice. The schistosomicidal activities of praziquantel, oxamniquine and antimony have been experimentally enhanced by the synergistic action of immune sera. In passive serum transfer experiments a s. mansoni antigen of Mr 27 kD with non-specific esterase activity was identified as a potentially sensitive target for the antibodies that interact with praziquantel. Indirect immunofluorescence indicated that this antigen was exposed on the worm surface as a result of praziquantel treatment.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Schistosoma mansoni
/
Esquistossomicidas
/
Esquistossomose mansoni
/
Anticorpos Anti-Helmínticos
/
Soros Imunes
Limite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
1989
Tipo de documento:
Article
/
Congress and conference