The rational search for natural neolignans
Mem. Inst. Oswaldo Cruz
;
86(supl.2): 25-29, 1991. ilus
Artigo
em Inglês
| LILACS
| ID: lil-623935
ABSTRACT
A rational method of search for natural neolignans of desired structures is outlined. This involves consultation of a collection of chemical profiles of plant families. The profiles are assembled considering the biosynthetic class (in the present case lignoids), subclass (neolignans), structural types (neolignan skeleta) and relative frequency of substitutional derivatives belonging to each type (known compounds). The method is of course applicable to ani class of natural products. Its use in the case of neolignans is here selected as an exemple in view of the recently discovered antagonism towards PAF of kadsurenone, a representative of this subclass of phytochemicals. Application of the chemical profiles to phylogenetic studies is illustrated.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Plantas
/
Proteínas Recombinantes
/
Lignanas
/
Compostos Fitoquímicos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1991
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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