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Effects of azadirachtin in Rhodnius prolixus: data and hypotheses
Garcia, E. S; Gonzales, M. S; Azambuja, P.
  • Garcia, E. S; Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro. BR
  • Gonzales, M. S; s.af
  • Azambuja, P; Universidade Federal Fluminense. Departamento de Biologia Geral. Niterói. BR
Mem. Inst. Oswaldo Cruz ; 86(supl.2): 107-111, 1991.
Artigo em Inglês | LILACS | ID: lil-623951
ABSTRACT
The effects of azadirachtin A, a tetranortriterpenoid from the neem tree Azadirachta indica J., on both development and interaction between Trypanosoma cruzi, the causative agent of Chagas' disease, and its vector Rhodnius prolixus were studied. Given through a blood meal, a dose-rsponse relationship of azadirachtin was established using antifeedant effect and ecdysis inhibition as effective parameters. A singlo dose of azadirachtin A was able to block the onset of mitosis in the epidermis and ecdysteroid titers in the hemnolymph, determined by radioimmuneassay, were too low for an induction of ecadysis. The survival of T. cruzi was also studied in R. prolixus treated with the drug. If the trypomastigotes were fed in presence of azadirachtin A the number of parasites drastically decreased. If the drug was applied after infection of the bug with T. cruzi, the parasite was still abolished from the gut. If the insect was pretreated with azadirachtin A before infection the same observation was obtained. A single dose of azadirachtin A was enough for a permanent resistance of the insect host against its reinfection with T. cruzi and for blocking the ecdysis for a long time. The effects of azadirachtin A on the hormonal balance of the host and growth inhibition of the parasite will be discussed on the basis of the present results.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Insetos Vetores / Inseticidas / Hormônios de Invertebrado / Sistemas Neurossecretores Limite: Animais Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 1991 Tipo de documento: Artigo / Congresso e conferência País de afiliação: Brasil Instituição/País de afiliação: Instituto Oswaldo Cruz/BR / Universidade Federal Fluminense/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Insetos Vetores / Inseticidas / Hormônios de Invertebrado / Sistemas Neurossecretores Limite: Animais Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 1991 Tipo de documento: Artigo / Congresso e conferência País de afiliação: Brasil Instituição/País de afiliação: Instituto Oswaldo Cruz/BR / Universidade Federal Fluminense/BR