Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats
Rev. bras. farmacogn
;
22(2): 412-417, Mar.-Apr. 2012. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-624651
ABSTRACT
The present study was carried out to evaluate the hepatoprotective activity of aqueous and ethanolic leaves extracts of Oxalis corniculata L., Oxalidaceae, against thioacetamide-induced hepatotoxicity. Hepatotoxicity was induced in Wistar rats of either sex by subcutaneous injection of thioacetamide. An aqueous and ethanolic extract of aerial parts of O. corniculata (200 and 400 mg/kg/day) were evaluated. Oral administration of O. corniculata aqueous and ethanolic leaves extract at 400 mg/kg resulted in a significant reduction in SGOT (146.42±2.54 and 136.75±1.37 IU/L respectively), SGPT (81.96±3.15 and 72.05±2.33 IU/L respectively), GGTP (16.6±0.49 and 15.02±0.68 IU/L respectively), ALP (241.86±3.94 and 202.42±5.37 IU/L respectively) and total bilirubin (0.226±0.00 mg/dL 0.288±0.01 mg/dL respectively) content that were lesser than positive control, thioacetamide damaged rats. Histology of the liver sections of the animals treated with the extract also showed dose dependent reduction of necrosis. Hence the study concluded that O. corniculata has potential hepatoprotective activity.
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Índice:
LILACS (Américas)
Idioma:
Inglês
Revista:
Rev. bras. farmacogn
Assunto da revista:
Farmácia
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Índia
Instituição/País de afiliação:
Karpagaram University/IN
/
St. John's Pharmacy College/IN
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