Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease
J. appl. oral sci
;
20(2): 128-138, Mar.-Apr. 2012. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-626410
ABSTRACT
Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies for inhibiting signal transduction pathways involved in inflammation. Pharmacological inhibitors of MAPK, NFκB and JAK/STAT pathways are being developed to manage rheumatoid arthritis, periodontal disease and other inflammatory diseases. Through these agents, inflammatory mediators can be inhibited at cell signaling level, interfering on transcription factors activation and inflammatory gene expression. Although these drugs offer great potential to modulate host response, their main limitations are lack of specificity and developments of side effects. After overcoming these limitations, adjunctive host modulating drugs will provide new therapeutic strategies for periodontal treatment.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doenças Periodontais
/
Transdução de Sinais
/
Mediadores da Inflamação
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Terapia de Alvo Molecular
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
Idioma:
Inglês
Revista:
J. appl. oral sci
Assunto da revista:
Odontologia
Ano de publicação:
2012
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
UNESP/BR
/
University of São Paulo/BR
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