Factores de virulencia de Mycobacterium tuberculosis / Virulence factors of Mycobacterium tuberculosis
Rev. méd. Chile
;
139(12): 1605-1610, dic. 2011.
Artigo
em Espanhol
| LILACS
| ID: lil-627597
ABSTRACT
Mycobacterium tuberculosis, the etiological agent of human tuberculosis, causes annually three million deaths and latently infects about two billion people. Immunodeficiency caused by malnutrition, senescence or co-infection with HIVenhances the risk of developing active tuberculosis, either from a primary infection or by reactivation of a latent infection. The increasing appearance of multidrug-resistant strains to existing drugs is worrisome, since it leaves patients practically without treatment options. The understanding of the mechanisms of transmission, pathogenesis and virulence of M. tuberculosis is important. The analysis of its genome shows the presence of alternative sigma factors, transcriptional repressors and activators, two component signaling systems, metabolic enzymes and cellular secretory systems, that are associated with virulence in a series of pathogenic micro-organisms. Environmental stimuli such as pH, temperature, osmolality, oxygen availability are processed, activating or repressing virulence genes. The molecular mechanisms of action of these genes have been elucidated in in vitro and in vivo models.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Fatores de Virulência
/
Mycobacterium tuberculosis
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Universidad San Sebastián/CL
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