Effect of calcium-entry blockers on the diurectic response to hydrochlorothiazide in the rat
Braz. j. med. biol. res
;
21(5): 1023-5, 1988. tab
Artigo
em Inglês
| LILACS
| ID: lil-63605
RESUMO
The influence of the calcium-entry blockers, verapamil, nifedipine and diltiazem on hydrochlorothiazide-induced diuresis was determined in hydrated conscious rats. Nifedipine significantly inhibited hydrochlorothiazide-induced 5-h excreted urine volume and urinary sodium with little effect on potassium excretion. Both verapamil and diltiazem significantly enhanced sodium excretion with no effects on either urine colume or potassium excretion. These results are of interest in view of the current use of nifedipine as an anti-hypertensive agent, alone or in combination with a thiazide diuretic
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Índice:
LILACS (Américas)
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Diurese
/
Hidroclorotiazida
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
/
Congresso e conferência
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