Early malnutrition alters the effect of chlordiazepoxide on inhibitory avoidance
Braz. j. med. biol. res
;
21(5): 1033-6, 1988. tab
Artigo
em Inglês
| LILACS
| ID: lil-63607
RESUMO
In order to study the functional consequences of brain changes caused by early malnutrition, rats were fed a protein-deficient diet from birth until 49 days of age and a balanced diet from day 50 to day 70. The animals were submitted to a step-down inhibitory avoidance task and to the flinch-jump nociceptive test at 49 and 70 days of age. Malnourished rats showed longer step-down latencies and lower flinch and junp theresholds than eutrophic animals. Chlordiazepoxide (5 mg/Kg, ip) shortened step-down latency of well-nourished rats, whereas it failed to do so in malnourished rats. Since well-nourished animals also became resistant to chlordiazepoxide when tested with a higher shock intensity, generating avoidance latencies comparable to those of malnourished animals, we conclude that the drug resistance induced by malnutrition may be secondary to enhanced pain sensitivity and/or reactivity
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Comportamento de Esquiva
/
Nociceptores
/
Clordiazepóxido
/
Desnutrição Proteico-Calórica
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS