Effect of metronidazole on the cell surface charge of Trichomonas vaginalis and Tritrichomonas foetus
Braz. j. med. biol. res
;
21(5): 1037-45, 1988. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-63608
RESUMO
1. The effect of metronidazole, a drug used in the treatment of trichomoniasis, on the surface chage of both Trichomonas vaginalis and Tritrichomonas foetus was analyzed by cell electrophoresis. 2. Incubation of the parasites under anaerobic conditions for 2 or 120 min in the presence of 2.0 microng/ml metronidazole, a concentration which inhibits cell growth by about 50%, led to a marked decrease in the net surface charge of the parasites. 3. The metronidazole analogue, 1-hydroxyethyl-2-methyl-1-4-inhibited protozoan growth but had no effect on met surface charge. 4. These observations indicate that, in addition to its effect on intracellular structure, cuch as hydrogenosomes, metronidazole alters the surface of trichomonads
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Índice:
LILACS (Américas)
Assunto principal:
Trichomonas vaginalis
/
Tritrichomonas
/
Metronidazol
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
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