Evidence for interaction between central beta-2 adrenoceptors and epinephrine patways in the opioid-induced prolactin rise in the rat
Braz. j. med. biol. res
;
21(5): 1057-63, 1988. ilus
Artigo
em Inglês
| LILACS
| ID: lil-63613
ABSTRACT
1. The possible role of central beta-2 adrenoceptors and epinephrine pathways in opioid-prolactin (PRL) rise was investigated. 2. FK 33824, a synthetic opioid peptide injected into the third ventricle of Wistar male rats, generated a PRL rise that was significantly reduced by pretreatment with IPS 339, a potent and selective beta-2 antagonist. 3. inhibition of central epinephrine synthesis with SKF 64 139, which selectively blocks phenylethanolamine-N-methyltransferase, partially decreased the PRL release induced by FK 33824. 4. Proctolol, a selective beta-1 adrenoceptor blocker, did not modify the PRL secretion induced by FK 33824. 5 The results indicate that this FK 33824 - induced PRL rise depends in part on the functional integrity of central beta-2 adrenoceptors and that epinephrine pathways in the brain may play an important role in the mechanisms by which opioid peptides increase PRL secretion
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LILACS (Américas)
Assunto principal:
Prolactina
/
Endorfinas
/
Epinefrina
/
Receptores Adrenérgicos beta
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
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