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Evidence for interaction between central beta-2 adrenoceptors and epinephrine patways in the opioid-induced prolactin rise in the rat
Braz. j. med. biol. res ; 21(5): 1057-63, 1988. ilus
Artigo em Inglês | LILACS | ID: lil-63613
ABSTRACT
1. The possible role of central beta-2 adrenoceptors and epinephrine pathways in opioid-prolactin (PRL) rise was investigated. 2. FK 33824, a synthetic opioid peptide injected into the third ventricle of Wistar male rats, generated a PRL rise that was significantly reduced by pretreatment with IPS 339, a potent and selective beta-2 antagonist. 3. inhibition of central epinephrine synthesis with SKF 64 139, which selectively blocks phenylethanolamine-N-methyltransferase, partially decreased the PRL release induced by FK 33824. 4. Proctolol, a selective beta-1 adrenoceptor blocker, did not modify the PRL secretion induced by FK 33824. 5 The results indicate that this FK 33824 - induced PRL rise depends in part on the functional integrity of central beta-2 adrenoceptors and that epinephrine pathways in the brain may play an important role in the mechanisms by which opioid peptides increase PRL secretion
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Índice: LILACS (Américas) Assunto principal: Prolactina / Endorfinas / Epinefrina / Receptores Adrenérgicos beta Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 1988 Tipo de documento: Artigo

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Índice: LILACS (Américas) Assunto principal: Prolactina / Endorfinas / Epinefrina / Receptores Adrenérgicos beta Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 1988 Tipo de documento: Artigo