Sodium dependence of eraly distal H+ secretion in rat kidney
Braz. j. med. biol. res
;
21(5): 1065-8, 1988. ilus
Artigo
em Inglês
| LILACS
| ID: lil-63614
ABSTRACT
In order to study the mechanism of H-ion secretion in cortical distal tubules of the rat kedney, the luminal pH and transepithelial potential difference (PD) were measured with double-barrelled, pH-sensitive, resin/reference microelectrodes. perfusion of peritubular capillaries with low-sodium solutions increased luminal pH by 0.28 ñ 0.024 units. Perfusion of the lumen with 1 m§ amiloride increased luminal pH by 0.67 ñ 0.01 units. These changes could not be atributed to modification of transepithelial PD. We conclude that early distal acidification is sodium-dependent, possibly owing to the presence of Na+/H+ exchange
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Índice:
LILACS (Américas)
Assunto principal:
Sódio
/
Amilorida
/
Concentração de Íons de Hidrogênio
/
Túbulos Renais Distais
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
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