Aspergilosis del sistema nervioso central: presentación de dos casos / Central nervous system aspergyllosis: presentation of two cases

ABSTRACT

Objective: to describe and analyze two cases of CNS aspergillosis.Description case 1 a 76 years old female, with a medical story of DM type 2 and high blood pressure, complained of headaches and left side hearing loss since 6 months before. The MRI showed a left temporal bone lesion that enhanced with contrast, including the petrous bone cerebellar surface. Case 2 a 23 years old female with an acute hepatic failure of unknown origin, ten days after she was transplanted went into coma, requiring endotraqueal intubation. A CT scan showed a bihemispheric subcortical hipodensity and a lumbar puncture showed hiperproteinoraquia with pleocitosis. Intervention. In case 1, a biopsy performed through a retrosigmoid approach was informed as aspergillosis. She received voriconazole. In case 2, at the 12° postoperative day a brain biopsy showed aspergillosis. The patient died on day 13° after surgery of multiorganic failure and cardio-respiratory arrest. The necropsy showed a disseminated aspergillosis infection that affected lungs, liver, heart, skin, brain, colon and kidneys. Conclusion: the results obtained with the treatment in both patients were in accordance with the outcome severity of aspergillosis as was described in the reports reviewed.