Intrinsically bent DNA in replication origins and gene promoters
Genet. mol. res. (Online)
;
7(2): 549-558, 2008. ilus
Artigo
em Inglês
| LILACS
| ID: lil-640982
ABSTRACT
Intrinsically bent DNA is an alternative conformation of the DNA molecule caused by the presence of dA/dT tracts, 2 to 6 bp long, in a helical turn phase DNA or with multiple intervals of 10 to 11 bp. Other than flexibility, intrinsic bending sites induce DNA curvature in particular chromosome regions such as replication origins and promoters. Intrinsically bent DNA sites are important in initiating DNA replication, and are sometimes found near to regions associated with the nuclear matrix. Many methods have been developed to localize bent sites, for example, circular permutation, computational analysis, and atomic force microscopy. This review discusses intrinsically bent DNA sites associated with replication origins and gene promoter regions in prokaryote and eukaryote cells. We also describe methods for identifying bent DNA sites for circular permutation and computational analysis.
Texto completo:
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Índice:
LILACS (Américas)
Assunto principal:
DNA
/
Regiões Promotoras Genéticas
/
Origem de Replicação
/
Conformação de Ácido Nucleico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Genet. mol. res. (Online)
Assunto da revista:
Biologia Molecular
/
Genética
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Centro Universitário de Maringá/BR
/
Universidade Estadual de Maringá/BR
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