Expression of Rap1GAP in human myeloid disease following microarray selection
Genet. mol. res. (Online)
;
7(2): 379-387, 2008. tab, ilus
Artigo
em Inglês
| LILACS
| ID: lil-641001
ABSTRACT
To find the underlying causes of primary myelodysplastic syndrome (MDS), the gene expression profiling of both CD34+ cells and bone marrow mononuclear cells from MDS patients was performed using oligonucleotide microarray and cDNA microarrays, respectively. Several candidate genes which were differentially expressed in MDS patients versus normal controls were selected and confirmed in expanding samples by quantitative real-time reverse transcription-polymerase chain reaction after clustering and bioinformatics analysis. one of these genes, RAP1GAP, was found to be expressed at a significantly higher level in patients with MDS in comparison with those suffering from other hematopoietic diseases including leukemia (P < 0.01). We propose that over-expression of RAP1GAP gene may play a role in the pathogenesis of MDS.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Síndromes Mielodisplásicas
/
Proteínas Ativadoras de GTPase
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Genet. mol. res. (Online)
Assunto da revista:
Biologia Molecular
/
Genética
Ano de publicação:
2008
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
China
Instituição/País de afiliação:
Soochow University/CN
Similares
MEDLINE
...
LILACS
LIS