Effects of a Mikania laevigata extract on bone resorption and RANKL expression during experimental periodontitis in rats
J. appl. oral sci
;
20(3): 340-346, May-June 2012. ilus
Artigo
em Inglês
| LILACS
| ID: lil-643731
ABSTRACT
OBJECTIVES: The Mikania laevigata extract (MLE) (popularly known in Brazil as "guaco") possesses anti-inflammatory properties. In the present study we tested the effects of MLE in a periodontitis experimental model in rats. We also investigated possible mechanisms underlying such effects. MATERIAL AND METHODS: Periodontal disease was induced by a ligature placed around the mandibular first molars of each animal. Male Wistar rats were divided into 4 groups: non-ligated animals treated with vehicle; non-ligated animals treated with MLE (10 mg/kg, daily); ligature-induced animals treated with vehicle and ligature-induced animals treated with MLE (10 mg/kg, daily). Thirty days after the induction of periodontal disease, the animals were euthanized and mandibles and gingival tissues removed for further analysis. RESULTS: Morphometric analysis of alveolar bone loss demonstrated that MLE-treated animals presented a decreased alveolar bone loss and a lower expression of the activator of nuclear factor-κB ligand (RANKL) measured by immunohistochemistry. Moreover, gingival tissues from the MLE-treated group showed decreased neutrophil migration myeloperoxidase (MPO) assay. CONCLUSIONS: These results indicate that MLE may be useful to control bone resorption during progression of experimental periodontitis in rats.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Periodontite
/
Reabsorção Óssea
/
Extratos Vegetais
/
Mikania
/
Ligante RANK
/
Anti-Inflamatórios
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
J. appl. oral sci
Assunto da revista:
Odontologia
Ano de publicação:
2012
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of Maranhão/BR
/
São Leopoldo Mandic Institute and Research Center/BR
/
University of São Paulo/BR
/
University of Uberaba/BR
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