Effects of intrauterine malnutrition on the renal morphology of Wistar rats: a systematic review
Braz. j. morphol. sci
;
28(1): 1-3, Jan.-Mar. 2011. tab
Artigo
em Inglês
| LILACS
| ID: lil-644123
ABSTRACT
Introduction:
Many epidemiological studies suggest that the intrauterine environment is extremely importantto the determination of the individuals future health. Alterations in the maternal nutritional state, reflectedon the weight on birth, may program the litter for the development of diseases on the adult age. Studies withanimals exposed to intrauterine malnutrition have suggested a reduction in the number of glomeruli, as wellas arterial pressure increase. To review in the literature the alterations of the renal physiology of adult Wistarrats exposed to malnourishment during intrauterine life. Material andmethods:
A search was performedin the following databases SciELO, MEDLINE, PUBMED, SCIENCE DIRECT and LILACS. The mainsearch terms were malnutrition and renal function both in Portuguese and in English. Were includedoriginal articles involving albino rats. Were excluded the review articles as well as those involving humanbeings.Results:
According to Franco et al. (2009) the renal function and the number of glomeruli werereduced by the intrauterine malnutrition, predisposing the adult animals to renal diseases. For Chen and Chou(2009) the glomerular ultrastructure is not affected by maternal undernutrition, suggesting that this factordoes not contribute to the hypertension pathogenesis after maternal malnutrition.Conclusion:
Intrauterinemalnourishment seems to interfere in the renal functions programming with alterations to the glomerulimorphology, but its mechanisms are yet uncertain. More randomized studies and clinical essays are suggestedin order to comprehend the factors that cause such process.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Zona Glomerulosa
/
Estudos Epidemiológicos
/
Desnutrição
/
Nefropatias
Tipo de estudo:
Estudo observacional
/
Revisões Sistemáticas Avaliadas
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
Braz. j. morphol. sci
Assunto da revista:
Anatomia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of Paraíba/BR
/
Federal University of Pernambuco/BR
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