Association of HLA antigens and BCR-ABL transcripts in leukemia patients with the Philadelphia chromosome
Rev. bras. hematol. hemoter
;
34(4): 280-284, 2012. tab
Artigo
em Inglês
| LILACS
| ID: lil-648527
ABSTRACT
OBJECTIVE:
This study aimed to verify the association between human leukocyte antigens and the bcr-abl fusion protein resulting from t(9;22)(q34;q11) in chronic leukemia myeloid and acute lymphoblastic leukemia patients.METHODS:
Forty-seven bcr-abl positive individuals were evaluated. Typing was performed bymicrolymphocytotoxicity and molecular biological methods (human leukocyte antigens Class I and Class II). A control group was obtained from the data of potential bone marrow donors registered in the Brazilian Bone Marrow Donor Registry (REDOME).RESULTS:
Positive associations with HLA-A25 and HLA-B18 were found for the b2a2 transcript, as well as a tendency towards a positive association with HLA-B40 and a negative association with HLA-A68. The b3a2 transcript showed positive associations with HLA-B40 and HLA-DRB1*3.CONCLUSION:
The negative association between human leukocyte antigens and the BCR-ABL transcript suggests that binding and presentation of peptides derived from the chimeric protein are effective to increase a cytotoxic T lymphocyte response appropriate for the destruction of leukemic cells.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cromossomo Filadélfia
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Leucemia
/
Leucemia Mieloide
/
Predisposição Genética para Doença
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Antígenos HLA
Tipo de estudo:
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Santa Maria/BR
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