Distinct subcellular localization of tRNA-derived fragments in the infective metacyclic forms of Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
107(6): 816-819, set. 2012. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-649500
ABSTRACT
Small non-coding RNAs derived from transfer RNAs have been identified as a broadly conserved prokaryotic and eukaryotic response to stress. Their presence coincides with changes in developmental state associated with gene expression regulation. In the epimastigote form of Trypanosoma cruzi, tRNA fragments localize to posterior cytoplasmic granules. In the infective metacyclic form of the parasite, we found tRNA-derived fragments to be abundant and evenly distributed within the cytoplasm. The fragments were not associated with polysomes, suggesting that the tRNA-derived fragments may not be directly involved in translation control in metacyclics.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Trypanosoma cruzi
/
RNA de Transferência
/
RNA de Protozoário
/
Grânulos Citoplasmáticos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Uruguai
Instituição/País de afiliação:
Fiocruz/BR
/
Institut Pasteur de Montevideo/UY
/
Universidade Federal do Paraná/BR
Similares
MEDLINE
...
LILACS
LIS