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Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
Mahesh, Ayyavu; Jeyachandran, Robert; Rao, Dowlathabad Muralidhara; Thangadurai, Devarajan.
  • Mahesh, Ayyavu; Madurai Kamaraj University. School of Biological Sciences. IN
  • Jeyachandran, Robert; St. Joseph's College. Department of Plant Biology and Plant Biotechnology. IN
  • Rao, Dowlathabad Muralidhara; Sri Krishnadevaraya University. Department of Biotechnology. IN
  • Thangadurai, Devarajan; Karnatak University. Department of Botany. Dharwad. IN
Rev. bras. farmacogn ; 22(5): 1085-1091, Sept.-Oct. 2012. ilus, tab
Artigo em Inglês | LILACS | ID: lil-649654
ABSTRACT
In the present study, the ethanolic root extract of Desmodium gangeticum (L.) DC., Fabaceae, (EDG), have been studied in various acute and chronic ulcer mouse models. Oral administration of root extract, significantly decrease the ulcer index and lesion number in a dose dependent manner against ethanol induced acute gastric ulcer in mice. In gastric ulcerated animal that received high dose of 150 mg/kg EDG, the mucosa showed no ulceration with slight focal congestion and the glands appeared normal. Pylorus ligated mice, pretreated with EDG showed significant decrease in ulcerous activity under chronic condition. The highest dose (150 mg/kg) of the extract provoked a marked increase in protein and glutathione levels, when compare to control. Furthermore, gastric juice, free acidity and total acid output were inhibited in a dose-dependent manner at p<0.05 level. Our results indicate that the EDG possess gastroprotective activity and increasing regeneration of damaged gastric mucosa and thus safe for human use.


Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Rev. bras. farmacogn Assunto da revista: Farmácia Ano de publicação: 2012 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Karnatak University/IN / Madurai Kamaraj University/IN / Sri Krishnadevaraya University/IN / St. Joseph's College/IN

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Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Rev. bras. farmacogn Assunto da revista: Farmácia Ano de publicação: 2012 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Karnatak University/IN / Madurai Kamaraj University/IN / Sri Krishnadevaraya University/IN / St. Joseph's College/IN