Consideraciones farmacocinéticas en el paciente crítico / Pharmacokinetic considerations in critically ill patients
Rev. méd. Chile
;
140(6): 780-788, jun. 2012. graf, tab
Artigo
em Espanhol
| LILACS
| ID: lil-649851
ABSTRACT
Background: Critically ill patients in Intensive Care Units (ICUs) are exposed to multiple procedures and usually require complex treatment regimens. Many of them suffer from comorbidities and different complications such as organ failure, drug-drug interactions, and unusual therapeutic interventions that can produce significant pathophysiologic changes. For that reason, pharmacokinetics for several substances is different to what is described for healthy patients, complicating drug selection and drug dosage to achieve appropriate effects. Low doses may determine a reduction of drug effectiveness and overdoses leading to toxicity. The aim of this paper is to review the pharmacokinetic considerations that must be considered when treating acute ICU patients.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Farmacocinética
/
Estado Terminal
/
Unidades de Terapia Intensiva
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2012
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Pontificia Universidad Católica de Chile/CL
/
Universidad de Chile/CL
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