The prevalence of thyroid autoimmunity in patients with prolactinoma
Appl. cancer res
;
30(4): 340-344, 2010.
Artigo
em Inglês
| LILACS, Inca
| ID: lil-658324
ABSTRACT
Prolactin (PRL) is a hormone characterized by its immunomodulatory properties. The aim of this study was to evaluate the prevalence of thyroid autoimmunity in patients with prolactinoma. Seventy-seven patients and 56 healthy individuals in the control group, sex and age matched, had their serum PRL, free tetraiodothyronine, thyroid-stimulating hormone and anti-thyroid peroxidase (anti-TPO) levels measured. The prevalence of anti-TPO for patients was 13% and 8.9% for control group (p = 0.58). The analysis of subgroups of patients, divided in accordance with tumor size at diagnosis, showed no significant difference in the frequency of anti-TPO. However, when they were divided in accordance with the prolactin levels at the moment of the study, 18.8% with valid hyperprolactinemia and 3.4% without hyperprolactinemia had positive autoantibody (p = 0.07). In conclusion, there was no greater prevalence of thyroid autoimmunity in patients with prolactinoma. Nevertheless, those with valid hyperprolactinemia showed a greater tendency for positive autoantibody anti-TPO
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Prolactina
/
Doenças Autoimunes
/
Doenças da Glândula Tireoide
/
Hiperprolactinemia
Tipo de estudo:
Estudo de prevalência
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Appl. cancer res
Assunto da revista:
Neoplasias
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Rio de Janeiro/BR
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