Hyponatremia, acute kidney injury, and mortality in HIV-related toxoplasmic encephalitis
Braz. j. infect. dis
;
16(6): 558-563, Nov.-Dec. 2012. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-658927
ABSTRACT
BACKGROUND:
There are no reports on hyponatremia and acute kidney injury (AKI) involved in the course of HIV-related toxoplasmic encephalitis (TE). The main objective of this study was to describe the occurrence of hyponatremia and its relationship with AKI and mortality in HIV-related toxoplasmic encephalitis (TE).METHODS:
This was a retrospective cohort study on patients with HIV-related TE. AKI was considered only when the RIFLE (risk, injury, failure, loss, end-stage) criterion was met, after the patient was admitted.RESULTS:
A total of 92 patients were included, with a mean age of 36 ± 9 years. Hyponatremia at admission was observed in 43 patients (46.7%), with AKI developing in 25 (27.1%) patients during their hospitalization. Sulfadiazine was the treatment of choice in 81% of the cases. Death occurred in 13 cases (14.1%). Low serum sodium level correlated directly with AKI and mortality. Male gender (OR 7.89, 95% CI 1.22-50.90, p = 0.03) and hyponatremia at admission (OR 4.73, 95% CI 1.22-18.30, p = 0.02) were predictors for AKI. Independent risk factors for death were AKI (OR 8.3, 95% CI 1.4-48.2, p < 0.0001) and hyponatremia (or 9.9, 95% ci 1.2-96.3, p < 0.0001).CONCLUSION:
AKI and hyponatremia are frequent in TE. Hyponatremia on admission is highly associated with AKI and mortality.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Toxoplasmose Cerebral
/
Infecções Oportunistas Relacionadas com a AIDS
/
Injúria Renal Aguda
/
Hiponatremia
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de Fortaleza/BR
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