Hematological differences between patients with different subtypes of sickle cell disease on hydroxyurea treatment
Rev. bras. hematol. hemoter
;
34(6): 426-429, 2012. tab
Artigo
em Inglês
| LILACS
| ID: lil-662718
ABSTRACT
OBJECTIVE:
Sickle cell anemia and the interaction S/Beta thalassemia differ in hematological values due to microcytosis and hypochromia caused by the thalassemic mutation. The clinical benefit of long-term hydroxyurea treatment is undeniable in sickle cell disease with monitoring of the biological action of the drug being by the complete blood count. The objective of this work is to compare changes in some of the erythrocytic indexes between S/Beta thalassemia and sickle cell anemia patients on long-term hydroxyurea treatment.METHODS:
The values of erythrocyte indexes (mean corpuscular volume and mean corpuscular hemoglobin) were compared in a retrospective study of two groups of patients (Sickle cell anemia and S/Beta thalassemia) on hydroxyurea treatment over a mean of six years.RESULTS:
The quantitative values of the two parameters differed between the groups. Increases in mean corpuscular volume and reductions in mean corpuscular hemoglobin delay longer in S/Beta thalassemia patients (p-value = 0.018).CONCLUSION:
Hematological changes are some of the beneficial effects of hydroxyurea in sickle cell disease as cellular hydration increases and the hemoglobin S concentration is reduced. The complete blood count is the best test to monitor changes, but the interpretation of the results in S/Beta thalassemia should be different.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Estudos Retrospectivos
/
Índices de Eritrócitos
/
Doença da Hemoglobina SC
/
Hemoglobinopatias
/
Hidroxiureia
/
Anemia Falciforme
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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