Novel insights into the genetic and epigenetic paternal contribution to the human embryo
Clinics
; 68(supl.1): 5-14, 2013.
Article
em En
| LILACS
| ID: lil-668033
Biblioteca responsável:
BR1.1
ABSTRACT
The integrity of the sperm genome and epigenome are critical for normal embryonic development. The advent of assisted reproductive technology has led to an increased understanding of the role of sperm in fertilization and embryogenesis. During fertilization, the sperm transmits not only nuclear DNA to the oocyte but also activation factor, centrosomes, and a host of messenger RNA and microRNAs. This complex complement of microRNAs and other non-coding RNAs is believed to modify important post-fertilization events. Thus, the health of the sperm genome and epigenome is critical for improving assisted conception rates and the birth of healthy offspring.
Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Espermatozoides
/
Desenvolvimento Embrionário
/
Fertilização
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Epigenômica
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2013
Tipo de documento:
Article