Experimental models in vaccine research: malaria and leishmaniasis
Braz. j. med. biol. res
;
46(2): 109-116, 01/fev. 2013.
Artigo
em Inglês
| LILACS
| ID: lil-668774
ABSTRACT
Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Leishmaniose Cutânea
/
Vacinas Antimaláricas
/
Vacinas contra Leishmaniose
/
Leishmaniose Visceral
/
Malária
Tipo de estudo:
Estudo prognóstico
/
Revisões Sistemáticas Avaliadas
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Fundação Oswaldo Cruz (FIOCRUZ)/BR
Similares
MEDLINE
...
LILACS
LIS