Does prolonged pneumoperitoneum affect the kidney? Oxidative stress, stereological and electron microscopy study in a rat model
Int. braz. j. urol
;
39(1): 30-36, January-February/2013. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-670375
ABSTRACT
Purpose:
Pneumoperitoneum (Pp) at 12 to 15 mmHg in rats is associated with kidney damage. However, Pp at 8 mmHg is now known to best correlate to working pressures used in humans. Thus the aim of this work was to study the kidney of rats submitted to prolonged Pp at 8 mmHg. Materials andMethods:
Rats were divided into a Sham group (n = 14), submitted to anesthesia, and a Pp group (n = 14), submitted to Pp at 8 mmHg, followed by deflation. In both groups, 7 animals were immediately killed and their kidneys were used for oxidative stress analyses. The remaining 7 rats in each group were evaluated after 6 weeks for the number of glomeruli and podocyte morphology.Results:
For all analyzed parameters Sham and Pp groups presented no statistical difference.Conclusion:
When submitted to adequate Pp pressures (8 mmHg), no kidney damage occurs in rats. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pneumoperitônio Artificial
/
Pressão
/
Estresse Oxidativo
/
Rim
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
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