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An extract of neem leaves reduces anxiety without causing motor side effects in an experimental model / Un extracto de hojas de neem reduce la ansiedad sin causar efectos colaterales motores en un modelo experimental
Thaxter, KA; Young, LE; Young, RE; Parshad, O; Addae, J.
  • Thaxter, KA; The University of the West Indies. Faculty of Medical Sciences. Department of Basic Medical Sciences. Kingston. JM
  • Young, LE; The University of the West Indies. Faculty of Medical Sciences. Department of Basic Medical Sciences. Kingston. JM
  • Young, RE; The University of the West Indies. Faculty of Medical Sciences. Department of Basic Medical Sciences. Kingston. JM
  • Parshad, O; The University of the West Indies. Faculty of Medical Sciences. Department of Basic Medical Sciences. Kingston. JM
  • Addae, J; The University of the West Indies. Faculty of Medical Sciences. Department of Basic Medical Sciences. Kingston. JM
West Indian med. j ; 59(3): 245-248, June 2010. ilus, tab
Artigo em Inglês | LILACS | ID: lil-672612
ABSTRACT
Anxiety modulation often requires pharmaceutical intervention, and though effective in the short term, benzodiazepines may cause impaired motor function. As a potential alternative, anxiety-modulating effects of a neem leaf (Azadirachta indica, A Juss) extract were investigated using ethological analysis of rat behaviour on an elevated X maze and compared with diazepam treatment. Sexually immature female Sprague-Dawley rats received 0.07 or 7 mg/kg neem leaf steroidal extract, a sham injection, a 1% DMSO/saline vehicle, 2 mg/kg diazepam or no treatment one hour prior to a recorded five-minute exploration of the elevated X maze. Neem matched diazepam in anxiety reduction as both treatments caused a decrease in per cent protected stretched-attend postures (PPSAP). Neem treatment had no effect on closed arm entries or total rears, distinguishing it pharmacologically from diazepam which resulted in a predictable decrease in those locomotor measures. Whereas both neem and diazepam reduced anxiety in complex ethological behavioural indices, only neem produced anxiolysis without motor deficiency.
RESUMEN
La modulación de la ansiedad requiere a menudo la intervención farmacéutica, y aunque eficaz a corto plazo, las benzodiazepinas pueden afectar la función motora. Como una alternativa potencial, los efectos moduladores de la ansiedad obtenidos a partir de un extracto de la hoja de neem (Azadirachta indica, A Juss), fueron investigados mediante análisis etiológico del comportamiento de ratas en un laberinto x elevado, y comparados con el tratamiento con diazepam. Ratas Sprague-Dawley hembras, sexualmente inmaduras, recibieron 0.07 ó 7 mg/kg de extracto esteroidal de hojas de neem, una inyección simulada, un vehículo salino de DMSO al 1%, 2 mg/kg de diazepam o ningún tratamiento una hora antes de registrarse una exploración de cinco minutos en el laberinto X elevado. El neem igualó al diazepam en la reducción de ansiedad, ya que ambos tratamientos causaron una disminución en las posturas de atención extremada protegida porcentual (PPSAP). El tratamiento de Neem no tuvo efecto sobre las entradas al brazo cerrado o actividades aéreas (con las patas traseras) distinguiéndose así farmacológicamente del diazepam que producía una disminución predecible en esas medidas locomotoras. Si bien tanto el neem como el diazepam reducían la ansiedad en los índices conductuales etológicos complejos, solamente el neem producía ansiolisis sin deficiencias motoras.
Assuntos

Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Ansiedade / Extratos Vegetais / Folhas de Planta / Azadirachta / Fitoterapia Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: West Indian med. j Assunto da revista: Medicina Ano de publicação: 2010 Tipo de documento: Artigo País de afiliação: Jamaica Instituição/País de afiliação: The University of the West Indies/JM

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Ansiedade / Extratos Vegetais / Folhas de Planta / Azadirachta / Fitoterapia Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: West Indian med. j Assunto da revista: Medicina Ano de publicação: 2010 Tipo de documento: Artigo País de afiliação: Jamaica Instituição/País de afiliação: The University of the West Indies/JM