Revisiting the Rich's formula: an update about granulomas in human tuberculosis
Braz. j. infect. dis
; Braz. j. infect. dis;17(2): 234-238, Mar.-Apr. 2013.
Article
em En
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| ID: lil-673203
Biblioteca responsável:
BR1.1
ABSTRACT
The formula proposed by Rich in 1951 explained the formation in a tuberculous lesion in a period that was unknown cellular functions, cytokines and other immunological aspects involved in granuloma formation by tuberculosis; its components are assembled conceptually to explain the pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. In this manuscript, we report an update of Rich's formula based on the new and old concepts about pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. Current knowledge allows us to conclude that the balance between the characteristics of the bacillus and host protective response is necessary to indicate the outcome of pathogenesis, infection or active disease and the necrosis degree of the tuberculosis lesion.
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Texto completo:
1
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LILACS
Assunto principal:
Tuberculose
/
Interações Hospedeiro-Patógeno
/
Mycobacterium tuberculosis
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Braz. j. infect. dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2013
Tipo de documento:
Article