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Detección rápida de metástasis en ganglio centinela y comparaciónde diferentes técnicas en carcinomas de mama de bajo grado / Rapid detection of sentinel lymph node metastases in different techniques and comparison in low-grade breast carcinomas
Sua, Luz Fernanda; Silva, Nhora; Vidaurreta, Martha; De la Orden, Virgina; Venganzones, Silvia; Rafael, Sara; Maestro de las casas, María.
  • Sua, Luz Fernanda; Fundación Clínica Valle del Lili. Clinical Laboratory and Pathology. Cali. CO
  • Silva, Nhora; Fundación Clínica Valle del Lili. Clinical Laboratory and Pathology. Cali. CO
  • Vidaurreta, Martha; Hospital Clínico San Carlos de Madrid. Clinical Analysis. Section of Genetics. Madrid. ES
  • De la Orden, Virgina; Hospital Clínico San Carlos de Madrid. Clinical Analysis. Section of Genetics. Madrid. ES
  • Venganzones, Silvia; Hospital Clínico San Carlos de Madrid. Clinical Analysis. Section of Genetics. Madrid. ES
  • Rafael, Sara; Hospital Clínico San Carlos de Madrid. Clinical Analysis. Section of Genetics. Madrid. ES
  • Maestro de las casas, María; Hospital Clínico San Carlos de Madrid. Clinical Analysis. Section of Genetics. Madrid. ES
Colomb. med ; 43(1): 28-37, Jan.-Mar. 2012. tab, graf
Artigo em Inglês | LILACS | ID: lil-673541
ABSTRACT

Introduction:

The role of sentinel node biopsy has revolutionized breast cancer treatment. This determinationreduces the mobility of a complete axillary lymphadenectomy. The aim of our study is to analyze the value of sentinel node in low-grade histological breast tumors, studied with hematoxylin and eosin techniques, mmunohistochemistry,and molecular chain reaction in real-time quantitative polymerase (RT-PCR). Materials and

methods:

In a pilot study we studied a total of 21 patients with histological diagnosis of mucinous carcinoma, adenoid cystic carcinoma, and medullar carcinoma that underwent the sentinel node technique. Once the lymph node was removed, it was sent to pathology, where it was fragmented and evaluated, using between 25% and 50% of the lymph node for molecular biology laboratory studies.

Results:

The sentinel nodes studied were 32, corresponding to the 21 patients. Of the 32 lymph nodes analyzed, 29 (90.6%) were negative on histopathological examination and the molecular identification, 2 (6.2%) were positive in both techniques and 1 (3.125%) lymph node was positive with quantitative RT-PCR and negative in histology (H&E), which – subsequently by immunohistochemistry (IHC) – was diagnosed as isolated tumor cells (ITC).

Conclusion:

When comparing the techniques of hematoxylin and eosin, immunohistochemistry, and molecularRT-PCR technique, we found greater sensitivity of molecular techniques; this can reduce the false negative andimprove diagnosis of sentinel node metastases. Patients with low histological grade carcinomas have high survivalrates, less aggressive tumor behavior, and reduced lymph node at diagnosis.
Assuntos

Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Biópsia / Neoplasias da Mama / Imuno-Histoquímica / Reação em Cadeia da Polimerase Tipo de estudo: Estudo diagnóstico Idioma: Inglês Revista: Colomb. med Assunto da revista: Medicina Ano de publicação: 2012 Tipo de documento: Artigo País de afiliação: Colômbia / Espanha Instituição/País de afiliação: Fundación Clínica Valle del Lili/CO / Hospital Clínico San Carlos de Madrid/ES

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Biópsia / Neoplasias da Mama / Imuno-Histoquímica / Reação em Cadeia da Polimerase Tipo de estudo: Estudo diagnóstico Idioma: Inglês Revista: Colomb. med Assunto da revista: Medicina Ano de publicação: 2012 Tipo de documento: Artigo País de afiliação: Colômbia / Espanha Instituição/País de afiliação: Fundación Clínica Valle del Lili/CO / Hospital Clínico San Carlos de Madrid/ES