ROC trials update on prehospital hypertonic saline resuscitation in the aftermath of the US-Canadian trials
Clinics
;
68(6): 883-886, jun. 2013.
Artigo
em Inglês
| LILACS
| ID: lil-676943
ABSTRACT
The objectives of this review are to assess the current state of hypertonic saline as a prehospital resuscitation fluid in hypotensive trauma patients, particularly after the 3 major Resuscitation Outcomes Consortium trauma trials in the US and Canada were halted due to futility. Hemorrhage and traumatic brain injury are the leading causes of death in both military and civilian populations. Prehospital fluid resuscitation remains controversial in civilian trauma, but small-volume resuscitation with hypertonic fluids is of utility in military scenarios with prolonged or delayed evacuation times. A large body of pre-clinical and clinical literature has accumulated over the past 30 years on the hemodynamic and, most recently, the anti-inflammatory properties of hypertonic saline, alone or with dextran-70. This review assesses the current state of hypertonic fluid resuscitation in the aftermath of the failed Resuscitation Outcomes Consortium trials.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ressuscitação
/
Solução Salina Hipertônica
/
Ensaios Clínicos como Assunto
/
Serviços Médicos de Emergência
Limite:
Humanos
País/Região como assunto:
América do Norte
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
U.S. Army Institute of Surgical Research/US
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