Atypical chronic myeloid leukemia with t(9; 22)(p24,11. 2), a BCR-JAK2 fusion gene
Rev. bras. hematol. hemoter
;
35(3): 218-219, jun. 2013. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-681980
ABSTRACT
We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and was submitted to an allogeneic bonemarrow transplantation. Fifty-three days after the procedure, he died due to acute graft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in only five patients in the whole world, with three clinical presentations myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloid leukemia.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Leucemia Mieloide
/
Proteínas Proto-Oncogênicas c-bcr
/
Leucemia Mieloide Crônica Atípica BCR-ABL Negativa
/
Doenças Mieloproliferativas-Mielodisplásicas
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Instituto HEMOMED/BR
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