Biomarcadores pronósticos de gravedad del dengue / Biomarkers for the prognosis of severe dengue
Biomédica (Bogotá)
;
33(supl.1): 108-116, set. 2013. graf, tab
Artigo
em Espanhol
| LILACS
| ID: lil-695802
RESUMEN
.
ABSTRACT
Introduction: There are very few strategies for the early detection of the patients who might develop the severe form of the illness. Objective: To evaluate the utility of serum levels of some immune response mediators as early biomarkers for the severe dengue prognosis during the early phase of the illness. Materials and methods: Using a case-control design nested in a multicenter cohort from the AEDES network (a Colombian multicenter study), we compared TNF a, ST2, TRAIL and IDO levels in samples which were obtained during the early phase of the illness. Results: ST2, TRAIL and TNF a levels were higher in severe dengue patients compared with uncomplicated patients (p<0.0001), as follows: OR=24.8, CI95%= 6.1- 98.0; OR=18.0, CI95%= 4.6-69.1; OR=NC, CI95%= NC, respectively. We did not find statistically significant differences between IDO levels in severe dengue and uncomplicated dengue (p=1.000, OR=1.0, CI95%= 0.2-6.1). Conclusions: In the early phase of the dengue infection (96 hours), ST2, TRAIL and TNF a quantifications could contribute to the prediction of complications of the illness.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Fator de Necrose Tumoral alfa
/
Receptores de Superfície Celular
/
Dengue Grave
/
Ligante Indutor de Apoptose Relacionado a TNF
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Biomédica (Bogotá)
Assunto da revista:
Medicina
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Colômbia
Instituição/País de afiliação:
Universidad Industrial de Santander/CO
Similares
MEDLINE
...
LILACS
LIS