Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
35(4): 432-434, Oct-Dec. 2013. tab
Artigo
em Inglês
| LILACS
| ID: lil-697323
ABSTRACT
Objective:
To investigate whether inpatients with disorganized schizophrenia are more resistant to treatment.Method:
Eighty-five inpatients were assessed at admission and at discharge for schizophrenia subtype, symptom severity, and treatment resistance criteria.Results:
Disorganized patients were significantly more treatment-resistant than paranoid patients (60%, p = 0.001), and presented worse scores on the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression Scale (CGI-S), and the Global Assessment of Functioning Scale (GAF) (p < 0.001). Although the difference was not significant, 80% of treatment-resistant patients with disorganized schizophrenia responded to clozapine.Conclusion:
Patients with the disorganized subtype of schizophrenia should benefit from clozapine as a second-line agent. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Esquizofrenia Hebefrênica
/
Esquizofrenia Paranoide
/
Antipsicóticos
/
Resistência a Medicamentos
/
Clozapina
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Sao Paulo (UNIFESP)/BR
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