Median lethal needle caliber in two models of experimental sepsis
Acta cir. bras
;
29(1): 1-6, 01/2014. graf
Artigo
em Inglês
| LILACS
| ID: lil-697561
ABSTRACT
To estimate the median lethal needle caliber (LC50) of a new experimental sepsis model and compare it to the LC50 of the cecal ligation and puncture (CLP) sepsis model. METHODS:
Male albino Wistar rats were studied (n=22). Animals were allocated into two study groups. In Group I, experimental sepsis was induced by cecal ligation and puncture. In Group II, experimental sepsis was induced by ascending colon ligation and cecal puncture. Up-and-down method was used to determinate the LC50.RESULTS:
LC50 in Group I was 19 Gauge (Confidence Interval 17 to 22 Gauge). Determination of LC50 was not possible in Group II due to the death of all animals.CONCLUSION:
LC50 in cecal ligation and puncture is 19 Gauge. The lethality of the new model tested in this trial is very high.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Patologia
/
Sepse
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Santa Catarina/BR
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