Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
Rev. bras. hematol. hemoter
;
35(6): 414-416, 2013. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-699991
ABSTRACT
Background:
The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking.Objective:
The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization.Methods:
This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels.Results:
The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index.Conclusion:
It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified. .
Texto completo:
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Índice:
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Assunto principal:
Transfusão de Sangue
/
Transfusão de Sangue Autóloga
/
Proteína C-Reativa
/
Transfusão de Eritrócitos
/
Alergia e Imunologia
/
Fenômenos do Sistema Imunitário
/
Isoanticorpos
/
Neoplasias
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hemocentro de Sao Paulo/BR
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